If you are using AMP for Endpoints in your lab or implementation, I would highly recommend adding the cloud connection to your Firepower Management Center. The reason you would do this is that it allows you to import threat identifications, indications of compromise (IOC), and other malware-related information that the AMP cloud gathers from the endpoints.
Firepower 6.0 pxGrid Integration with ISE - CA-Signed Certificate
In this post, I'm going to go through the configuration of Firepower v6.0.x for pxGrid integration with ISE using CA-signed certificates. In future posts, I'm planning on going through the configuration for both Firepower 5.4 and 6.0 using both self-signed and CA-signed certificates. The reason I plan on doing that is because they are slightly different and it's important to know this.